Published On: Tue, Aug 2nd, 2016

Study shows cell-free DNA sequencing is some-more accurate for diagnosing myelodysplastic syndrome

Using next-generation sequencing (NGS) methods to investigate cell-free DNA in a blood of patients with myelodysplastic syndrome (MDS) yields some-more accurate formula than a stream customary proceed of Sanger sequencing. This finding, and a larger odds of detecting a genetic monstrosity obliged for a commotion by examining cell-free DNA contra DNA extracted from a patient’s blood cells, is reported in a new investigate published in Genetic Testing and Molecular Biomarkers, a peer-reviewed biography from Mary Ann Liebert, Inc., publishers. The essay is accessible giveaway on a Genetic Testing and Molecular Biomarkers website until Aug 30, 2016.

Ferras Albitar, Maher Albitar, and coauthors from NeoGenomics Laboratories, Irvine, CA, compared 3 techniques for identifying a DNA mutations compared with MDS, a organisation of cancers inspiring a bone marrow. Accurate research of a molecular abnormalities in patients with MDS can assist in early diagnosis and assistance beam studious care. Both cell-free and mobile DNA from a carcenogenic cells in a bone pith are strew into a patient’s blood.

In a essay “Deep Sequencing of Cell-Free Peripheral Blood DNA as a Reliable Method for Confirming a Diagnosis of Myelodysplastic Syndrome” a researchers introduce that NGS be deliberate as a process of choice for sequencing cell-free DNA to endorse a diagnosis of MDS.

“This is a conspicuous anticipating that cell-free DNA provides a some-more supportive test for detecting cancer than does a normal proceed of examining cell-associated DNA,” says Genetic Testing and Molecular Biomarkers Editor-in-Chief Garth D. Ehrlich, PhD, FAAAS, Center for Genomic Sciences and Center for Advanced Microbial Processing, Institute for Molecular Medicine and Infectious Disease, Drexel College of Medicine (Philadelphia, PA).

Source: Mary Ann Liebert, Inc./Genetic Engineering News

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