Published On: Mon, Jan 7th, 2019

First person

ABSTRACT

First Person is a array of interviews with a initial authors of a preference of papers published in Biology Open, assisting early-career researchers foster themselves alongside their papers. Klytaimnistra Kiouptsi is initial author on ‘Hypoxia evokes increasing PDI and PDIA6 countenance in a infarcted myocardium of ex-germ-free and conventionally lifted mice’, published in BiO. Klytaimnistra is a postdoc in a lab of Christoph Reinhardt during a Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Germany, questioning tummy microbiota and a purpose in cardiovascular disease.

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Klytaimnistra Kiouptsi

What is your systematic credentials and a ubiquitous concentration of your lab?

I reason a Master’s grade in Biotechnology from a University of Ioannina in Greece. My seductiveness in thrombosis investigate and platelet duty led me to enrol in a PhD programme during a Mainz Research School of Translational Biomedicine. During my PhD in a lab of Christoph Reinhardt during a Center for Thrombosis and Hemostasis in Mainz, we investigated a purpose of a tummy microbiota in compelling arterial thrombosis and a import in myocardial infarction. More specifically, we complicated a hypoxia-dependent law of protein disulphide isomerase expression. That was when we initial started training about a tummy microbiome and a ability of microbes to change cardiovascular functions and thrombus growth. Prof. Reinhardt uses his gnotobiotic trickery to try a change of tummy microbes in thrombosis and cardiovascular disease.

“[…] a change of a tummy microbiota is not usually limited to a intestine though also affects other organs’ functions.”

How would we explain a categorical commentary of your paper to non-scientific family and friends?

During myocardial infarction, that is ordinarily famous as a heart attack, there is decreased blood upsurge to one partial of a heart, ensuing in low oxygen and nutritious supply, that causes repairs to a heart muscle. However, there are certain molecules during a site of infarction, that strengthen a heart from going into hypoxic stress. In a study, we identified one of these factors, namely PDIA6. We suggested that a change of a tummy microbiota is not usually limited to a intestine though also affects other organs’ functions. Using hygienic rodent models, a investigate showed that a microbiota contributes to increasing PDIA6 countenance in a infarcted rodent heart.

What are a intensity implications of these formula for your margin of research?

Based on a results, it will be engaging to try how a colonization with a tummy microbiota, a ongoing inflammatory stimulus, affects platelet duty and a growth of cardiovascular disease. So far, comparatively small is famous on a change that this microbial ecosystem exerts on vascular phenotypes.

What has astounded we a many while conducting your research?

It is many fascinating to me to comprehend that a tummy microbiota has remote effects, heading to adaptive changes in apart organs. Our laboratory was means to denote that platelet deposition in arterial thrombosis and cardiovascular functions are shabby by a tummy microbiota.

What, in your opinion, are some of a biggest achievements in your margin and how has this shabby your research?

Gnotobiotic isolator record is a absolute apparatus to brand host-microbial interactions and to pinpoint a mechanisms that colonizing tummy microbes change in a host. Combined with genetic models and with determined methods to investigate organ functions, gnotobiotics will allege new insights in a area of vascular physiology.

What changes do we consider could titillate a veteran lives of early-career scientists?

Major problems in academia are a limited series of grants, short-term contracts for researchers and low remuneration, in multiple with a really severe time schedule. These obstacles mostly titillate rarely prepared and splendid people to find their career trail in a opposite field. A resolution would be to boost appropriation to yield long-term perspectives to successful scientists. This will not usually titillate a peculiarity of publications, though will also lead to simple investigate that is of high originality.

What’s subsequent for you?

At this point, we am on maternity leave as my second child was innate during a finish of October. we am looking brazen to returning to a lab once my daughter is comparison and has a mark in day care.

Figure1

Immunohistochemistry dirty for protein disulphide isomerase (PDI) in sham-operated (left) and left maiden forward artery (LAD)-ligated (right) heart tissue.

Footnotes

  • Klytaimnistra Kiouptsi’s hit details: Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.

    E-mail: klytaimnistra.kiouptsi{at}unimedizin-mainz.de

Reference

    1. Kiouptsi, K.,
    2. Finger, S.,
    3. Garlapati, V. S.,
    4. Knorr, M.,
    5. Brandt, M.,
    6. Walter, U.,
    7. Wenzel, P. and
    8. Reinhardt, C.

    (2019). Hypoxia evokes increasing PDI and PDIA6 countenance in a infarcted myocardium of ex-germ-free and conventionally lifted mice. Biology 8, bio038851. doi:10.1242/bio.38851

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