The role of retrograde intraflagellar transport genes in aminoglycoside-induced hair cell death [RESEARCH ARTICLE]

INTRODUCTION During development, hair cells – the sensory cells of the auditory and vestibular systems – contain a single primary cilium on their apical surface known as the kinocilium. Primary cilia are microtubule-based structures that are believed to be important for cellular signaling in other cell types (Satir and Christensen, 2007). The kinocilium More...

by Kalen Beh | Published 1 week ago
By Kalen Beh On Monday, January 14th, 2019
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Local deformation and stiffness distribution in fly wings [RESEARCH ARTICLE]

INTRODUCTION Most insect wings are flexible, non-cambered, flat structures, producing aerodynamic forces for locomotion during gliding and wing flapping at elevated frequencies. They consist of thin membranes and More...

By Kalen Beh On Monday, January 14th, 2019
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Influence of substrate orientation on tadpoles’ feeding efficiency [RESEARCH ARTICLE]

INTRODUCTION The external oral apparatus of most anuran larvae is comprised of a soft, marginally papillated oral disc that surrounds keratinized jaw sheaths and rows of keratinized labial teeth (McDiarmid and Altig, More...

By Kalen Beh On Monday, January 14th, 2019
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The 17{beta}-estradiol induced upregulation of the adhesion G-protein coupled receptor (ADGRG7) is modulated by ESR{alpha} and SP1 complex [RESEARCH ARTICLE]

INTRODUCTION Adolescent idiopathic scoliosis (AIS) is a complex three-dimensional deformity of the spine that mostly occurs during late childhood or puberty (Konieczny et al., 2013). Severe forms of AIS are more More...

By Kalen Beh On Thursday, January 10th, 2019
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First person

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Yunlong Li More...

By Kalen Beh On Thursday, January 10th, 2019
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The ATPase TER94 regulates Notch signaling during Drosophila wing development [RESEARCH ARTICLE]

DISCUSSION The data presented here described the TER94 ATPase as a novel regulator of the Notch signaling pathway in Drosophila. Although Drosophila TER94 acts broadly to regulate the activity of Hh, Wg and BMP More...

By Kalen Beh On Tuesday, January 8th, 2019
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Improved dynamic monitoring of transcriptional activity during longitudinal analysis in the mouse brain [METHODS AND TECHNIQUES]

DISCUSSION Using a combination of a modified lentiviral luciferase reporter and stereotaxic microinjection, we successfully demonstrated robust and dynamic brain GR activation in response to acute stress in mice. More...

By Kalen Beh On Monday, January 7th, 2019
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Contribution of non-circadian neurons to a temporal classification of locomotor activity [RESEARCH ARTICLE]

DISCUSSION Rhythmic rest-activity cycles are a outcome of a concurrent activity of opposite neuronal clusters, a supposed time neurons (Grima et al., 2004; Shafer et al., 2006; Stoleru et al., 2004; Yao and Shafer, More...

By Kalen Beh On Monday, January 7th, 2019
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Localized clutter of a cochlear middle hair dungeon synaptic segment after sound bearing [RESEARCH ARTICLE]

DISCUSSION Our prior work regulating 3D nucleus microscopy (Bullen et al., 2015) suggested an organized intracellular surface system. The placement of mitochondria was compared with this system, and surface placement More...

By Kalen Beh On Monday, January 7th, 2019
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Genome-wide marker of lncRNAs and mRNAs differentially voiced in non-functioning pituitary adenoma and construction of an lncRNA-mRNA co-expression network [RESEARCH ARTICLE]

DISCUSSION The impasse of lncRNAs during tumorigenesis is a new rising thesis (Yoshimizu et al., 2008; Kim et al., 2013). Similar to exemplary oncogenes or tumor-suppressor genes such as eIF4F (eukaryotic interpretation More...