Dominant-negative inhibition of canonical Notch signaling in trophoblast cells does not disrupt placenta formation [RESEARCH ARTICLE]

INTRODUCTION The development and function of the placenta relies heavily on embryo-derived trophoblasts (TBs), specialized cells that interact with maternal endothelial cells (ECs) to form mosaic vessels that facilitate proper blood flow to a developing conceptus (Cha et al., 2012; Cross et al., 1994; Hunkapiller and Fisher, 2008; Rai and Cross, 2014). More...

by Kalen Beh | Published 2 years ago
By Kalen Beh On Monday, April 8th, 2019
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Motion characteristics of human roller skating [RESEARCH ARTICLE]

Cover article – Serum-based inhibition of pitviper venom by eastern indigo snakes (Drymarchon couperi) Image credit Scott Goetz: an eastern indigo snake (Drymarchon couperi). Scott Goetz and colleagues confirm More...

By Kalen Beh On Thursday, April 4th, 2019
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Distinct gene-selective roles for a network of core promoter factors in Drosophila neural stem cell identity [RESEARCH ARTICLE]

DISCUSSION Control of developmental gene expression is thought to rely on the combinatorial action of gene-specific transcription factors. The concerted action of activators and repressors is thought to ultimately More...

By Kalen Beh On Monday, April 1st, 2019
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Simultaneous expression of ClopHensor and SLC26A3 reveals the nature of endogenous oxalate transport in CHO cells [METHODS AND TECHNIQUES]

INTRODUCTION The fluorescent fusion protein, ClopHensor, has previously been reported as a promising tool for simultaneous measurement of intracellular chloride and pH in live cells (Arosio et al., 2010; Mukhtarov More...

By Kalen Beh On Monday, April 1st, 2019
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Effect of intracerebroventricular epinephrine microinjection on blood pressure and urinary sodium handling in gestational protein-restricted male adult rat offspring [RESEARCH ARTICLE]

DISCUSSION The interaction between environmental and genetic factors interfere in ontogenic development, leading to morphofunctional disorders in tissues and organs in adulthood. Gestational protein restriction More...

By Kalen Beh On Wednesday, March 27th, 2019
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First person

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Leon Green More...

By Kalen Beh On Wednesday, March 27th, 2019
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First person

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Barbara Torsello More...

By Kalen Beh On Wednesday, March 27th, 2019
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First person – Mei

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Mei-Fang Lin More...

By Kalen Beh On Wednesday, March 27th, 2019
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Alteration of 28S rRNA 2′-O-methylation by etoposide correlates with decreased SMN phosphorylation and reduced Drosha levels [RESEARCH ARTICLE]

INTRODUCTION The major types of modifications in human rRNA are pseudouridylation and 2′-O ribose methylation. Human rRNA contains around 100 of each of these modifications, which are performed by small nucleolar More...

By Kalen Beh On Wednesday, March 27th, 2019
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The 1ALCTL and 1BLCTL isoforms of Arg/Abl2 induce fibroblast activation and extra cellular matrix remodelling differently [RESEARCH ARTICLE]

DISCUSSION During the fibrosis process myofibroblasts, the activated form of fibroblasts continue to produce ECM resulting in abnormal scar tissue deposition. Myofibroblasts also occur in the context of growing More...