Folic acid modifies the shape of epithelial cells during morphogenesis via a Folr1 and MLCK dependent mechanism [RESEARCH ARTICLE]

INTRODUCTION Neural tube defects (NTDs) are a group of structural birth defects characterized by a failure of the early neural plate to undergo its normal morphogenetic program leading to spina bifida, anencephaly, and craniorachischisis. Notably, maternal dietary folic acid supplementation reduces the risk of NTDs in offspring of human populations More...

by Kalen Beh | Published 2 days ago
By Kalen Beh On Thursday, January 17th, 2019
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First person

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Sarah Hoffmann More...

By Kalen Beh On Thursday, January 17th, 2019
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GFP-Forked, a genetic reporter for studying Drosophila oocyte polarity [METHODS AND TECHNIQUES]

INTRODUCTION Correct localization of intracellular messenger RNAs (mRNAs) encoding morphogenetic proteins to their distinct subcellular domains are crucial for specification of the body axes of the Drosophila embryo. More...

By Kalen Beh On Thursday, January 17th, 2019
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Maintenance of cell fates and regulation of the histone variant H3.3 by TLK kinase in Caenorhabditis elegans [RESEARCH ARTICLE]

INTRODUCTION Defects in cell-fate maintenance cause aberrant cell-fate transformation, which can induce tumor formation and tissue malfunction. Conversely, suppression of the mechanisms that maintain cell fate is More...

By Kalen Beh On Thursday, January 17th, 2019
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Three-dimensional movements of the pectoral fin during yaw turns in the Pacific spiny dogfish, Squalus suckleyi [RESEARCH ARTICLE]

INTRODUCTION The morphology and movement of control surfaces (structures that adjust an organism’s position in space) in swimming vertebrates have profound effects on stability and maneuverability (Webb and More...

By Kalen Beh On Tuesday, January 15th, 2019
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IL-31 plays dual roles in lung inflammation in an OVA-induced murine asthma model [RESEARCH ARTICLE]

DISCUSSION In this study, we first investigated IL-31 levels in peripheral blood and expression of IL-31RA in the lungs of mice undergoing allergic airway inflammation following 8 consecutive weeks of intranasal More...

By Kalen Beh On Monday, January 14th, 2019
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First person

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Eriko Seo is More...

By Kalen Beh On Monday, January 14th, 2019
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Roles of Keber’s valve and foot chamber for foot manipulation in the mussel Nodularia douglasiae [RESEARCH ARTICLE]

INTRODUCTION The main functions of the circulation system are (1) convection of solutes and heat, and (2) transmission of forces (Schmidt-Nielsen, 1983). The Mollusca Bivalvia has an open circulatory system and More...

By Kalen Beh On Monday, January 14th, 2019
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First person

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Amani Hassan More...

By Kalen Beh On Monday, January 14th, 2019
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Treatment with methyl-{beta}-cyclodextrin prevents mechanical allodynia in resiniferatoxin neuropathy in a mouse model [RESEARCH ARTICLE]

INTRODUCTION A specialized microdomain which has cholesterol-rich membrane regions contains several transmembrane molecules that modulate cellular physiology. Evidence suggests that microdomains serve as organizing More...